학술논문
POCl3 MEDIATED STAUDINGER REACTION OF IMINES WITH KETENES: SYNTHESIS OF MONOCYCLIC β-LACTAM AND 1, 3-OXAZINONE DERIVATIVES.
Document Type
Article
Source
Subject
*BETA lactamases
*IMINE synthesis
*OXAZINES
*OXAZINONES
*RING formation (Chemistry)
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Language
ISSN
0974-1496
Abstract
Monocyclic β-lactams commonly referred to as azetidin-2-ones and their derivatives have been extensively explored for their wide biological applications. The present study demonstrates a simple and efficient synthesis of monocyclic β-lactam derivatives via Staudinger reaction, well characterized by FT-IR, 1H, 13C-NMR, mass spectral data and elemental analysis. We also confirmed the formation of highly substituted 1,3-oxazin-4-ones under the same reaction conditions. [ABSTRACT FROM AUTHOR]