학술논문
Genome-wide detection and family clustering of ion channels
Document Type
Article
Author
Source
Subject
*ION channels
*GENOMICS
*
Language
ISSN
0014-5793
Abstract
Ion channels represent an important class of molecules that can be classified into 13 distinct groups. We present a strategy using a ‘learning set’ of well-annotated ion channel sequences to detect homologues in 32 entire genome sequences from Archaea, Bacteria and Eukarya. A total of 299 putative ion channel protein sequences were detected, with significant variations across species. The clustering of these sequences reveals complex relationships between the different ion channel families. [Copyright &y& Elsevier]