부산대학교 도서관

Targeted disruption of the different ER genes has generated experimental animal models that are very useful in evaluating the distinct and cooperative roles of the two estrogen receptors, ERα and ERβ, in reproductive but also non-reproductive tissues of both sexes. Phenotypic analysis has provided definitive experimental findings for estrogen receptor mediated physiological actions, involving ERα in uterine, mammary gland and neuroendocrine sites. ERβ is involved most dramatically in the ovary as is ERα. More detailed studies in combination with tissue specific or inducible ER knock outs will be important for future research. [Copyright &y& Elsevier]