학술논문
Durability of Immune Responses After Boosting in Ad26.COV2.S-Primed Healthcare Workers.
Document Type
Article
Author
Sablerolles, Roos S G; Rietdijk, Wim J R; Goorhuis, Abraham; Postma, Douwe F; Visser, Leo G; Schmitz, Katharina S; Geers, Daryl; Bogers, Susanne; Haren, Eva van; Koopmans, Marion P G; Dalm, Virgil A S H; Kootstra, Neeltje A; Huckriede, Anke L W; Akkerman, Renate; Beukema, Martin; Lafeber, Melvin; Baarle, Debbie van; Vries, Rory D de; Kuy, P Hugo M van der; GeurtsvanKessel, Corine H
Source
Subject
*COVID-19
*IMMUNOGLOBULINS
*COVID-19 vaccines
*TIME
*IMMUNE system
*RESEARCH funding
*DRUG allergy
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Language
ISSN
1058-4838
Abstract
The emergence of SARS-CoV-2 variants raised questions regarding the durability of immune responses after homologous or heterologous boosters after Ad26.COV2.S-priming. We found that SARS-CoV-2–specific binding antibodies, neutralizing antibodies, and T cells are detectable 5 months after boosting, although waning of antibodies and limited cross-reactivity with Omicron BA.1 was observed. [ABSTRACT FROM AUTHOR]