부산대학교 도서관

(h) The plaque on the right forearm disappeared after 6 months of combination therapy. gl Granted the mechanism of this combination therapy remains unclear, it could nevertheless accelerate the treatment period compared to thermotherapy alone; the combination therapy took 6 months and the thermotherapy alone took 1 year.1 Note that metastatic/disseminated infection should be excluded especially in heavily immunocompromised patients prior to use of local therapy.5 This combination therapy could be a safe and effective treatment option for cutaneous alternariosis, especially in post-transplantation patients. Cutaneous alternariosis is a phaeohyphomycosis caused by I Alternaria i species and occurs predominantly in immunocompromised patients, as I Alternaria i species are only weakly pathogenic.1-3 Treatment of alternariosis remains challenging.1-4 Organ transplantation accompanied with immunosuppressive treatments is an important risk factor for alternariosis T incidence rate.4 Post-transplantation patients often have difficulty withstanding systemic antifungal therapy; amphotericin B potentially causes renal toxicity, and itraconazole can interact pharmacologically with immunosuppressive treatments.1 Torres-Rodríguez et al. reported a case of subcutaneous alternariosis treated with persistent thermotherapy without antifungal treatment.1 Suda et al. reported a case of cutaneous alternariosis initially treated with itraconazole (200 mg/day p.o.), which was later switched to voriconazole (400 mg/day p.o.). Successful thermotherapy combined with terbinafine hydrochloride 1% cream for cutaneous alternariosis in a post-transplantation patient. [Extracted from the article]