학술논문
The effect of MC1R variants and sunscreen on the response of human melanocytes in vivo to ultraviolet radiation and implications for melanoma.
Document Type
Article
Author
Source
Subject
*MELANOMA diagnosis
*CLINICAL trials
*COMPARATIVE studies
*MELANOCYTES
*KERATINOCYTES
*DNA damage
*PHYSIOLOGICAL effects of ultraviolet radiation
*CANCER cell proliferation
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Language
ISSN
1755-1471
Abstract
We conducted a clinical trial to compare the molecular and cellular responses of human melanocytes and keratinocytes in vivo to solar-simulated ultraviolet radiation ( SSUVR) in 57 Caucasian participants grouped according to MC1R genotype. We found that, on average, the density of epidermal melanocytes 14 days after exposure to 2 minimal erythemal dose ( MED) SSUVR was twofold higher than baseline (unirradiated) skin. However, the change in epidermal melanocyte counts among people carrying germline MC1R variants (97% increase) was significantly less than those with wild-type MC1R (164% increase; P = 0.01). We also found that sunscreen applied to the skin before exposure to 2 MED SSUVR completely blocked the effects of DNA damage, p53 induction, and cellular proliferation in both melanocytes and keratinocytes. [ABSTRACT FROM AUTHOR]