학술논문
HIV-Associated Microbial Translocation May Affect Cytokine Production of CD56bright NK Cells via Stimulation of Monocytes.
Document Type
Article
Author
ToVinh, Michael; Hörr, Gregor; Hoffmeister, Christoph; Dobrikova, Kristiyana; Gotter, Christina; Raabe, Jan; Kaiser, Kim M; Ahmad, Sarah; Finnemann, Claudia; Matejec, Eyleen; Hack, Gudrun; Bischoff, Jenny; Rieke, Gereon J; Schwarze-Zander, Carolynne; Boesecke, Christoph; Bremen, Kathrin van; Wasmuth, Jan-Christian; Eis-Hübinger, Anna M; Streeck, Hendrik; Verhasselt, Hedda L
Source
Subject
*KILLER cells
*HIV infections
*CELL physiology
*CYTOKINES
*MONOCYTES
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Language
ISSN
0022-1899
Abstract
The mechanisms involved in HIV-associated natural killer (NK) cell impairment are still incompletely understood. We observed HIV infection to be associated with increased plasma levels of IFABP, a marker for gut epithelial barrier dysfunction, and LBP, a marker for microbial translocation. Both IFABP and LBP plasma concentrations were inversely correlated with NK cell interferon-γ production, suggesting microbial translocation to modulate NK cell functions. Accordingly, we found lipopolysaccharide to have an indirect inhibitory effect on NK cells via triggering monocytes' transforming growth factor-β production. Taken together, our data suggest increased microbial translocation to be involved in HIV-associated NK cell dysfunction. [ABSTRACT FROM AUTHOR]