학술논문
Disruption of the circadian clock drives Apc loss of heterozygosity to accelerate colorectal cancer.
Document Type
Article
Author
Sung Kook Chun; Fortin, Bridget M.; Fellows, Rachel C.; Habowski, Amber N.; Verlande, Amandine; Song, Wei A.; Mahieu, Alisa L.; Lefebvre, Austin E. Y. T.; Sterrenberg, Jason N.; Velez, Leandro M.; Digman, Michelle A.; Edwards, Robert A.; Pannunzio, Nicholas R.; Seldin, Marcus M.; Waterman, Marian L.; Masri, Selma
Source
Subject
*WNT signal transduction
*CLOCK genes
*CLOCKS & watches
*COLORECTAL cancer
*NICOTINAMIDE
*HETEROZYGOSITY
*BIOCHEMISTRY
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Language
ISSN
2375-2548
Abstract
The article reports that An alarming rise in young onset colorectal cancer (CRC) has been reported; however, the underlying molecular mechanism remains undefined. Suspected risk factors of young onset CRC include environmental aspects, such as lifestyle and dietary factors, which are known to affect the circadian clock.