학술논문
Prevalence of non-falciparum malaria infections among asymptomatic individuals in four regions of Mainland Tanzania.
Document Type
Article
Author
Popkin-Hall, Zachary R.; Seth, Misago D.; Madebe, Rashid A.; Budodo, Rule; Bakari, Catherine; Francis, Filbert; Pereus, Dativa; Giesbrecht, David J.; Mandara, Celine I.; Mbwambo, Daniel; Aaron, Sijenunu; Lusasi, Abdallah; Lazaro, Samwel; Bailey, Jeffrey A.; Juliano, Jonathan J.; Gutman, Julie R.; Ishengoma, Deus S.
Source
Subject
*MALARIA
*PLASMODIUM falciparum
*SOCIAL surveys
*INFECTION
*PLASMODIUM vivax
*PLASMODIUM
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Language
ISSN
1756-3305
Abstract
Background: Recent studies point to the need to incorporate the detection of non-falciparum species into malaria surveillance activities in sub-Saharan Africa, where 95% of the world's malaria cases occur. Although malaria caused by infection with Plasmodium falciparum is typically more severe than malaria caused by the non-falciparum Plasmodium species P. malariae, P. ovale spp. and P. vivax, the latter may be more challenging to diagnose, treat, control and ultimately eliminate. The prevalence of non-falciparum species throughout sub-Saharan Africa is poorly defined. Tanzania has geographical heterogeneity in transmission levels but an overall high malaria burden. Methods: To estimate the prevalence of malaria species in Mainland Tanzania, we randomly selected 1428 samples from 6005 asymptomatic isolates collected in previous cross-sectional community surveys across four regions and analyzed these by quantitative PCR to detect and identify the Plasmodium species. Results: Plasmodium falciparum was the most prevalent species in all samples, with P. malariae and P. ovale spp. detected at a lower prevalence (< 5%) in all four regions; P. vivax was not detected in any sample. Conclusions: The results of this study indicate that malaria elimination efforts in Tanzania will need to account for and enhance surveillance of these non-falciparum species. [ABSTRACT FROM AUTHOR]