학술논문
Disabled 1 Is Part of a Signaling Pathway Activated by Epidermal Growth Factor Receptor.
Document Type
Article
Author
Source
Subject
*EPIDERMAL growth factor receptors
*APOLIPOPROTEIN E
*LOW density lipoprotein receptors
*EPIDERMAL growth factor
*ADAPTOR proteins
*APOLIPOPROTEIN E4
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*
*
*
*
Language
ISSN
1661-6596
Abstract
Disabled 1 (Dab1) is an adapter protein for very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2) and an integral component of the Reelin pathway which orchestrates neuronal layering during embryonic brain development. Activation of Dab1 is induced by binding of Reelin to ApoER2 and VLDLR and phosphorylation of Dab1 mediated by Src family kinases. Here we show that Dab1 also acts as an adaptor for epidermal growth factor receptor (EGFR) and can be phosphorylated by epidermal growth factor (EGF) binding to EGFR. Phosphorylation of Dab1 depends on the kinase activity of EGFR constituting a signal pathway independent of Reelin and its receptors. [ABSTRACT FROM AUTHOR]