부산대학교 도서관

Background: An increasing prevalence of disorders such as Alzheimer's is still to be addressed through effective syntheticbased therapeutics which are not hazardous. Objective: The aim of this research was to study the phytochemicals, physiochemical and memory enhancing activity Amaranthus spinosus. Material and Methods: At different doses of 250-2000 mg/kg body weight, an ethanolic extract of the whole plant was extracted and used for physiochemical, phytochemical, and acute oral toxicity studies. For memory enhancement evaluation, two doses (250 and 500 mg/kg body weight p.o) were given to each group of animals for seven days. Histopathology was also performed. Shankpushpi syrup 200 mg/kg body weight was taken as standard. Results: A phytochemical investigation of the entire plant extract reveals tannins account for 6.07 percent, saponins for 53 percent, alkaloids for 13.14 percent, proteins for 16.76 percent, and glycosides for 63.2 percent. Total phenolic content (TPC) was 2.81 in GAE, g/100 g, and total flavonoid content (TFC) was found 18.4 QE, g/100 g extracts. The lethal dose (LD50) of A. spinosus ethanolic extract was determined to be >2000 mg/kg, showing that it would be very safe when given acutely. When compared to the control group (37.80±0.51, 705.75±12.56), the dose of ethanolic extract of A. spinosus 500 mg/kg p.o reduced the number of errors and latency (32.79±0.54, 469.91±10.29). In a histopathological investigation, the control group's brain section was compared to the treatment group's brain section, and there were apparent alterations in the number of pyramidal cells. Conclusion: This study demonstrates memory enhancer potential of Amaranthus Spinosus extract. [ABSTRACT FROM AUTHOR]