학술논문
Diffuse Alveolar Haemorrhage with ANCA associated vaculitis-review of Literature.
Document Type
Article
Author
Source
Subject
*ALVEOLAR process
*GRANULOMATOSIS with polyangiitis
*DYSPNEA
*VASCULAR diseases
*RESPIRATORY diseases
*PROTEOLYTIC enzymes
*WOUNDS & injuries
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Language
ISSN
1757-8515
Abstract
Patients with Wegner's Granulomatosis often present with diffuse alveolar haemorrhage alongside the classical triad of haemoptysis, anaemia and progressive dyspnoea. The diagnosis is confirmed by bronchoalveolar lavage with serial aspirated aliquots of fluid revealing persistently bloody returns. Lung biopsy is very helpful if it shows granulomatous inflammation and vasculitis however it lacks sensitivity and specificity. Studies suggest that the detection of antineutrophilcytoplasmic antibodies (ANCA) along with Proteinase-3 can substitute for biopsy for the diagnosis of Wegner's Granulomatosis in patients who present with diffuse alveolar haemorrhage. [ABSTRACT FROM AUTHOR]