학술논문
Safety and preliminary immunogenicity of MenC/P64k, a meningococcal serogroup C conjugate vaccine with a new recombinant carrier.
Document Type
Article
Author
Source
Subject
*NEISSERIA meningitidis
*NEISSERIA
*BACTERIAL vaccines
*IMMUNOLOGY
*MEDICAL microbiology
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Language
ISSN
0928-8244
Abstract
This study reports the preliminary assessment of the safety and immunogenicity of the first serogroup C conjugate vaccine candidate that includes meningococcal P64k recombinant protein as the carrier (MenC/P64k). Twenty volunteers were recruited for a double-blind, randomized, controlled phase I clinical trial, receiving a single dose of MenC/P64k (study group) and a single dose of the commercial polysaccharide vaccine AC (control group). Only mild reactions were observed. No statistical differences were detected between the antipolysaccharide C IgG responses of both groups as well as between bactericidal serum titre ( P>0.05). The MenC/P64k vaccine was found to have a good safety profile, to be well tolerated and immunogenic. [ABSTRACT FROM AUTHOR]