학술논문
An efficient synthesis of 8-substituted Odoratine derivatives by the Suzuki coupling reaction.
Document Type
Article
Author
Source
Subject
*SUBSTITUTION reactions
*SUZUKI reaction
*COUPLING reactions (Chemistry)
*NUCLEAR magnetic resonance
*CHEMICAL structure
*BROMINATION
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Language
ISSN
0974-3626
Abstract
An efficient method for the preparation of 8-substituted odoratine [(3-(3 , 4 -methylenedioxyphenyl)-5,6,7-trimethoxyisoflavone] derivatives, structurally similar to glaziovianin A, a known cytotoxic substance, has been described. The key steps in the synthesis are site selective bromination reaction followed by Suzuki coupling reaction in very good yield. The structural assignment of the bromo derivative was determined utilizing 2D-HMBC and NOEs NMR techniques. [Figure not available: see fulltext.] [ABSTRACT FROM AUTHOR]