학술논문
Incidence, clinical and biological characteristics and outcome of secondary acute lymphoblastic leukemia after solid organ or hematologic malignancy.
Document Type
Article
Author
Kelleher, Nicholas; Gallardo, David; González-Campos, José; Hernández-Rivas, Jesús M.; Montesinos, Pau; Sarrá, Josep; Gil, Cristina; Barba, Pere; Guàrdia, Ramon; Brunet, Salut; Bernal, Teresa; Martínez, Maria-Pilar; Abella, Eugènia; Bermúdez, Arantxa; Sánchez-Delgado, Magdalena; Antònia, Cladera; Gayoso, Jorge; Calbacho, María; Ribera, Josep-Maria
Source
Subject
*LYMPHOBLASTIC leukemia
*HUMAN cytogenetics
*PROGNOSIS
*CANCER chemotherapy
*RADIOTHERAPY
*PATIENTS
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Language
ISSN
1042-8194
Abstract
Acute lymphoblastic leukemia (ALL) following solid organ or hematologic malignancy (secondary ALL, s-ALL) is not well characterized. We analyzed the characteristics and outcome of patients with s-ALL and compared them with those of patients with de novo- ALL. Of 448 patients, 24 (5%) had previous neoplasia. Sixteen patients had received previous cytotoxic therapy (therapy-associated ALL, t-ALL), and eight had not (antecedent-malignancy ALL, am-ALL). Except for more advanced age in patients with s-ALL, no statistically significant differences were observed in WBC count, CNS involvement, immunophenotype or cytogenetics between the groups, nor in complete remission (t-ALL: 94%; am-ALL: 75%; de novo-ALL: 85%), 3-year remission duration (58%; 50%; 72%), overall survival (71%; 38%; 60%) or event-free survival (53%, 38%; 53%). Our study did not show poor clinical or cytogenetic features or inferior outcome in ALL patients with antecedent neoplastic disease, irrespective of the type of treatment received for the neoplasia. [ABSTRACT FROM AUTHOR]