학술논문
Associations of Maternal Educational Level, Proximity to Green Space During Pregnancy, and Gestational Diabetes With Body Mass Index From Infancy to Early Adulthood: A Proof-of-Concept Federated Analysis in 18 Birth Cohorts.
Document Type
Article
Author
Cadman, Tim; Elhakeem, Ahmed; Vinther, Johan Lerbech; Avraam, Demetris; Carrasco, Paula; Calas, Lucinda; Cardol, Marloes; Charles, Marie-Aline; Corpeleijn, Eva; Crozier, Sarah; Castro, Montserrat de; Estarlich, Marisa; Fernandes, Amanda; Fossatti, Serena; Gruszfeld, Dariusz; Guerlich, Kathrin; Grote, Veit; Haakma, Sido; Harris, Jennifer R; Heude, Barbara
Source
Subject
*NATURE
*BODY mass index
*RESEARCH funding
*GESTATIONAL diabetes
*DESCRIPTIVE statistics
*META-analysis
*PSYCHOLOGY of mothers
*CONFIDENCE intervals
*MEDICAL screening
*EDUCATIONAL attainment
*REGRESSION analysis
*DISEASE complications
*ADOLESCENCE
*CHILDREN
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Language
ISSN
0002-9262
Abstract
International sharing of cohort data for research is important and challenging. We explored the feasibility of multicohort federated analyses by examining associations between 3 pregnancy exposures (maternal education, exposure to green vegetation, and gestational diabetes) and offspring body mass index (BMI) from infancy to age 17 years. We used data from 18 cohorts (n = 206,180 mother-child pairs) from the EU Child Cohort Network and derived BMI at ages 0–1, 2–3, 4–7, 8–13, and 14–17 years. Associations were estimated using linear regression via 1-stage individual participant data meta-analysis using DataSHIELD. Associations between lower maternal education and higher child BMI emerged from age 4 and increased with age (difference in BMI z score comparing low with high education, at age 2–3 years = 0.03 (95% confidence interval (CI): 0.00, 0.05), at 4–7 years = 0.16 (95% CI: 0.14, 0.17), and at 8–13 years = 0.24 (95% CI: 0.22, 0.26)). Gestational diabetes was positively associated with BMI from age 8 years (BMI z score difference = 0.18, 95% CI: 0.12, 0.25) but not at younger ages; however, associations attenuated towards the null when restricted to cohorts that measured gestational diabetes via universal screening. Exposure to green vegetation was weakly associated with higher BMI up to age 1 year but not at older ages. Opportunities of cross-cohort federated analyses are discussed. [ABSTRACT FROM AUTHOR]