부산대학교 도서관

GA is an idiopathic non-infectious granulomatous skin disease with an annual incidence of 0.04% in the United States.[2] Skin lesions are mostly localized and self-resolving but disseminated GA (>=10 lesions) is present in 15% of those affected.[[1]] In contrast to localized GA, disseminated GA is often refractory to conventional treatments.[1] Finding an effective treatment remains difficult because the GA pathogenesis has not yet been fully elucidated. The efficacy of other JAK inhibitors, such as tofacitinib and upadacitinib, in the treatment of GA lesions has also been described (Table 1).[[3], [5], [7], [9]] This case underlines the favourable therapeutic potential of pathway-specific treatment of rare inflammatory diseases. In this table, we summarize prior case reports of GA treatment with JAK inhibitors and their outcome. [Extracted from the article]