학술논문
The effect of TGFβRI inhibition on extracellular matrix structure and stiffness in hypertrophic scar-specific fibroblast-derived matrix models.
Document Type
Article
Author
Source
Subject
*HYPERTROPHIC scars
*EXTRACELLULAR matrix
*SECOND harmonic generation
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Language
ISSN
0006-291X
Abstract
• A scar-specific FDM model was used to test the in vitro efficacy of ALK5 exon skipping. • ALK5 exon 2 skipping reduced parallel orientation of collagen in the HTS-FDM model. • ALK5 inhibition reduced the stiffness of the hypertrophic scar specific matrix models. [ABSTRACT FROM AUTHOR]