학술논문
Rice (Oryza sativa L.) bran preserves cardiac function by modulating pro-inflammatory cytokines and redox state in the myocardium from obese rats.
Document Type
Article
Author
Source
Subject
*MYOCARDIUM physiology
*OBESITY complications
*RICE
*CYTOKINES
*INTERLEUKINS
*ANIMAL experimentation
*INFLAMMATION
*SUPEROXIDE dismutase
*DIETARY supplements
*RATS
*DIETARY sucrose
*MALONDIALDEHYDE
*CATALASE
*CARDIAC output
*TUMOR necrosis factors
*INFLAMMATORY mediators
*OXIDATION-reduction reaction
*DIETARY fats
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Language
ISSN
1436-6207
Abstract
Purpose: This study aimed to evaluate the effect of rice bran (RB) supplementation to a high-sugar fat (HSF) diet on cardiac dysfunction in an experimental obesity model. Methods: Male Wistar rats were distributed into three groups: control, high-sugar fat, and high-sugar fat supplemented with 11% RB for 20 weeks. Results: HSF diet promoted obesity and metabolic complications. Obese rats showed cardiac structural and functional impairment associated with high levels of interleukin-6, tumoral necrosis factor alpha, and malondialdehyde, and decreased activity of superoxide dismutase and catalase in the myocardium. RB supplementation was able to mitigate obesity and its metabolic alterations in HSF diet-fed animals. Moreover, the RB also prevented structural and functional damage, inflammation, and redox imbalance in the heart of these animals. Conclusion: This study suggests that RB supplementation prevents cardiac dysfunction in rats fed on HSF by modulating systemic metabolic complications and inflammation and oxidative stress in the myocardium, representing potential alternative therapy. [ABSTRACT FROM AUTHOR]