학술논문
Chronic Stress Accelerates Atherosclerosis in the Apolipoprotein E Deficient Mouse.
Document Type
Article
Author
Source
Subject
*PHYSIOLOGICAL stress
*ATHEROSCLEROSIS
*CORONARY disease
*APOLIPOPROTEIN E
*ATHEROSCLEROTIC plaque
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*
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Language
ISSN
1025-3890
Abstract
Conventional cardiovascular risk factors such as cholesterol and blood pressure do not account fully for variation in coronary heart disease suggesting the involvement of additional mechanisms. We have examined the effects of a chronic psychological stress protocol on the development of atherosclerosis in the apolipoprotein E knockout mouse. We observed a 3-fold increase in staining for atheroma accompanied by a 10-fold increase in corticosterone concentrations in mice stressed for 12 weeks. These data suggest that chronic mild stress can induce or accelerate the development of atherosclerosis. [ABSTRACT FROM AUTHOR]