학술논문
www.rnaworkbench.com: A new program for analyzing RNA interference
Document Type
Article
Author
Vařeková, Radka Svobodová; Bradáč, Ivan; Plchút, Martin; Škrdla, Michal; Wacenovsky, Michael; Mahr, Helmuth; Mayer, Georg; Tanner, Herbert; Brugger, Hermann; Withalm, Josef; Lederer, Peter; Huber, Heinrich; Gierlinger, Gerhard; Graf, Ronald; Tafer, Hakim; Hofacker, Ivo; Schuster, Peter; Polčík, Martin
Source
Subject
*COMPUTER software
*COMPUTER systems
*ELECTRONIC data processing
*ELECTRONIC commerce software
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Language
ISSN
0169-2607
Abstract
Abstract: RNA interference (RNAi) has become an important tool to study and utilize gene silencing by introducing short interfering RNA (siRNA). In order to predict the most efficient siRNAs, a new software tool, RNA Workbench (RNAWB), has been designed and is freely available (after registration) on http://www.rnaworkbench.com. In addition to the standard selection rules, RNAWB includes the possibility of statistical analyses of the applied selection rules (criteria). The role of RNA secondary structures in the RNA interference process as well as the application of sequence rules are discussed to show the applicability of the software. [Copyright &y& Elsevier]