학술논문
Nirmatrelvir-resistant SARS-CoV-2 variants with high fitness in an infectious cell culture system.
Document Type
Article
Author
Yuyong Zhou; Gammeltoft, Karen Anbro; Ryberg, Line Abildgaard; Pham, Long V.; Tjørnelund, Helena Damtoft; Binderup, Alekxander; Hernandez, Carlos Rene Duarte; Fernandez-Antunez, Carlota; Offersgaard, Anna; Fahnøe, Ulrik; Peters, Günther Herbert Johannes; Ramirez, Santseharay; Bukh, Jens; Gottwein, Judith Margarete
Source
Subject
*CELL culture
*SARS-CoV-2
*SARS-CoV-2 Delta variant
*SARS-CoV-2 Omicron variant
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Language
ISSN
2375-2548
Abstract
The article presents a study which explores the Nirmatrelvir-resistant SARS-CoV-2 variants with high fitness in an infectious cell culture system. It mentions that oral protease inhibitor nirmatrelvir as of key importance for prevention of severe coronavirus disease 2019. It discusses that findings of the study have implications for monitoring and ensuring treatments with efficacy against SARS-CoV-2 and emerging sarbecoviruses.