학술논문
Mycolactone cytotoxicity in Schwann cells could explain nerve damage in Buruli ulcer.
Document Type
Article
Author
Source
Subject
*SCHWANN cells
*BURULI ulcer
*CELL death
*APOPTOSIS
*MACROPHAGES
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Language
ISSN
1935-2727
Abstract
Buruli ulcer is a chronic painless skin disease caused by Mycobacterium ulcerans. The local nerve damage induced by M. ulcerans invasion is similar to the nerve damage evoked by the injection of mycolactone in a Buruli ulcer mouse model. In order to elucidate the mechanism of this nerve damage, we tested and compared the cytotoxic effect of synthetic mycolactone A/B on cultured Schwann cells, fibroblasts and macrophages. Mycolactone induced much higher cell death and apoptosis in Schwann cell line SW10 than in fibroblast line L929. These results suggest that mycolactone is a key substance in the production of nerve damage of Buruli ulcer. [ABSTRACT FROM AUTHOR]