학술논문
Antitumor Activity of a Polymer Composite of Etoposide and Biodegradable Poly(Lactide-Co-Glycolide).
Document Type
Article
Author
Source
Subject
*ETOPOSIDE
*ANTINEOPLASTIC agents
*CELL-mediated cytotoxicity
*DRUG resistance
*IN vivo studies
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Language
ISSN
0091-150X
Abstract
A method for preparing an antitumor polymer form of etoposide (PFE) as submicron particles based on poly(lactide-co-glycolide) with a 50:50 ratio of monomers (PLGA 50/50) was described. It was shown that the PFE possessed high cytotoxicity against various types of human tumor cells. The activity of the PFE against multiple drug resistant K562 cell line was greater than that of free etoposide. A grafted solid P388 murine lymphatic leukemia model showed that the PFE exhibited high in vivo antitumor activity that was prolonged compared with that of free etoposide. [ABSTRACT FROM AUTHOR]