부산대학교 도서관

Aim: This study aimed to examine physical activity (PA), physical fitness and cardiometabolic risk amongst people with moderate and severe haemophilia (PwMSH). Methods: The following domains were examined: PA (accelerometry); functional aerobic capacity (6‐Minute Walk Test); grip strength (dynamometry); balance (One Leg Stand Test); body composition (anthropometry and bioimpedance analysis); blood pressure; arterial stiffness; and cardiometabolic disorders. Results: A total of 53 PwMSH (44 years) and 33 controls (43 years; p =.679) were recruited. Compared to controls, PwMSH were significantly less active in moderate and vigorous PA parameters (all p <.05), and less physically fit indicated by 6‐Minute Walk distance (p <.0005), grip strength (p =.040) and balance (p <.0005). PwMSH had higher rates of abdominal adiposity compared to controls measured by waist circumference indices (all p <.05). Resting blood pressure and arterial stiffness were not significantly different (p =.797 and.818, respectively). With respect to overall PA, World Health Organisation recommended targets for adults were achieved by the majority of both groups (haemophilia: 72.9% vs. controls: 90.0%; p =.069). Importantly, the number of PwMSH who achieved guideline recommended PA via longer, sustained bouts of moderate–vigorous PA was significantly lower compared to controls (18.8% vs. 56.7%; p =.001). Lastly, clinically diagnosed hypertension, insulin resistance and hyperlipidaemia were more prevalent amongst PwMSH compared to controls. Conclusion: Low levels of PA and physical fitness, and significant rates of abdominal adiposity and hypertension may collectively influence the risk and severity of various cardiometabolic and/or musculoskeletal health issues amongst ageing PwMSH. Personalised multi‐disciplinary health interventions involving PA, dietary and health psychology input for PwMSH warrant future investigation. [ABSTRACT FROM AUTHOR]