학술논문
Annexin‐A1: The culprit or the solution?
Document Type
Article
Author
Source
Subject
*PEPTIDE receptors
*AUTOIMMUNE diseases
*T cells
*IMMUNE system
*PEPTIDES
*INFLAMMATION
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Language
ISSN
0019-2805
Abstract
Annexin‐A1 has a well‐defined anti‐inflammatory role in the innate immune system, but its function in adaptive immunity remains controversial. This glucocorticoid‐induced protein has been implicated in a range of inflammatory conditions and cancers, as well as being found to be overexpressed on the T cells of patients with autoimmune disease. Moreover, the formyl peptide family of receptors, through which annexin‐A1 primarily signals, has also been implicated in these diseases. In contrast, treatment with recombinant annexin‐A1 peptides resulted in suppression of inflammatory processes in murine models of inflammation. This review will focus on what is currently known about annexin‐A1 in health and disease and discuss the potential of this protein as a biomarker and therapeutic target. [ABSTRACT FROM AUTHOR]