학술논문
Brief Report: The Prevalence of Neurofibromatosis Type 1 among Children with Autism Spectrum Disorder Identified by the Autism and Developmental Disabilities Monitoring Network.
Document Type
Report
Author
Source
Subject
*AUTISM
*COMPARATIVE studies
*CONFIDENCE intervals
*DEVELOPMENTAL disabilities
*GOODNESS-of-fit tests
*CLASSIFICATION of mental disorders
*NONVERBAL communication
*PROBABILITY theory
*REGRESSION analysis
*RESEARCH funding
*T-test (Statistics)
*MATHEMATICAL variables
*COMORBIDITY
*DATA analysis software
*MEDICAL coding
*NEUROFIBROMATOSIS 1
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Language
ISSN
0162-3257
Abstract
Neurofibromatosis type 1 (NF1) is an inherited neurocutaneous disorder associated with neurodevelopmental disorders including autism spectrum disorder (ASD). The frequency of ASD/NF1 co-occurrence has been subject to debate since the 1980s. This relationship was investigated in a large population-based sample of 8-year-old children identified with ASD (N = 12,271) by the Centers for Disease Control and Prevention's Autism and Developmental Disabilities Monitoring (ADDM) Network. Twenty-two (1-in-558) children with ASD had diagnosed NF1, exceeding NF1 general population estimates by four to five fold. Children with ASD/NF1 versus ASD without NF1 were significantly less likely to receive a community-based ASD diagnosis ( p = 0.04) and understand non-verbal communication ( p = 0.001). These findings underscore the importance of including social-communication ability among relevant developmental concerns in children with NF1. [ABSTRACT FROM AUTHOR]