학술논문
1,3-oxazole derived cytisines.
Document Type
Article
Source
Subject
*CHEMICAL reactions
*ACYLAMINO compounds
*ALKALOIDS
*CYTISINE
*OXAZOLES synthesis
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Language
ISSN
1070-3632
Abstract
Reactions of 1-acylamino-2,2-dichloroacrylonitriles, diethyl 1-acylamino-2,2,2-trichloroethyl-phosphonates and 1-acylamino-2,2-dichloroethenylphosphonium salts with natural alkaloid cytisine have been studied. A series of novel multifunctional cytisine derivatives containing pharmacophore 1,3-oxazole moiety have been obtained. Composition and structure of the synthesized compounds have been confirmed by mass spectrometry and NMR spectroscopy data. [ABSTRACT FROM AUTHOR]