학술논문
Education of lymphocytes in vivo following a transient take of a matched unrelated bone-marrow graft in man.
Document Type
Article
Author
Source
Subject
*ANEMIA
*BONE marrow
*TRANSPLANTATION of organs, tissues, etc.
*IMMUNE response
*CELLS
*LYMPHOCYTES
*HLA histocompatibility antigens
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Language
ISSN
0009-9104
Abstract
A patient suffering from aplastic anaemia was treated by bone-marrow transplantation from an ABO- and HLA-identical, MLC- and CML-negative, unrelated donor, MLC and CML became positive after transplantation indicating that a cellular immune response had developed against lymphocyte determinants not recognized prior to sensitization in vivo. Whether these determinants are governed by genes of the HLA region is unknown at present. [ABSTRACT FROM AUTHOR]