학술논문
A polyphenotypic malignant paediatric brain tumour presenting a MN1‐PATZ1 fusion, no epigenetic similarities with CNS High‐Grade Neuroepithelial Tumour with MN1 Alteration (CNS HGNET‐MN1) and related to PATZ1‐fused sarcomas.
Document Type
Article
Author
Source
Subject
*SARCOMA
*FOLLICULAR dendritic cells
*TUMORS
*CANCER
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Language
ISSN
0305-1846
Abstract
A polyphenotypic malignant paediatric brain tumour presenting a MN1-PATZ1 fusion, no epigenetic similarities with CNS High-Grade Neuroepithelial Tumour with MN1 Alteration (CNS HGNET-MN1) and related to PATZ1-fused sarcomas Central nervous system high-grade neuroepithelial tumour with I MN1 i alteration (CNS HGNET-MN1) is a brain tumour methylation class that has recently been identified, based on (epi)genetic profiles of a large CNS-PNETs cohort [1]. In addition, the tumour exhibited a polyphenotypic immunoprofile, a feature described in CNS HGNET-MN1 [4] but also pointing toward other tumour entities, such as atypical teratoid rhabdoid tumour or I CIC-NUTM1 i sarcoma [5]. [Extracted from the article]