부산대학교 도서관

An emerging problem for human health is the exposure to non-regulated mineral fibers with an asbestos-like crystal habit, particularly fibrous zeolites. This study aimed to determine if and how selected fibrous zeolites (erionite, mesolite, and thomsonite) induce toxicity effects on two different in vitro cellular models, the adherent murine hippocampal (HT22) and human immortalized T lymphocyte (Jurkat) cell lines. Before proceeding with the cellular tests, the three zeolite samples were investigated using scanning electron microscopy–energy-dispersive spectroscopy and X-ray powder diffraction techniques. The cells were treated with 0.1 µM and 1 µM of fibrous erionite, mesolite, and thomsonite for 12, 24, and 48 h. Results showed a cytotoxic effect of erionite in both cellular models and revealed different toxic behaviors of the mesolite and thomsonite fibers, suggesting other potential mechanisms of action. The outcome of this study would be a first step for further research on fine biochemical interactions of zeolite fibers with cells and future in vivo investigations. [ABSTRACT FROM AUTHOR]