학술논문
EARLY- ESLI study: Long-term experience with eslicarbazepine acetate after first monotherapy failure.
Document Type
Article
Author
Villanueva, V.; Bermejo, P.; Montoya, J.; Toledo, M.; Gómez‐Ibáñez, A.; Garcés, M.; Vilella, L.; López‐González, F. J.; Rodriguez‐Osorio, X.; Campos, D.; Martínez, P.; Giner, P.; Zurita, J.; Rodríguez‐Uranga, J.; Ojeda, J.; Mauri, J. A.; Camacho, J. L.; Ruiz‐Giménez, J.; Poza, J. J.; Massot‐Tarrús, A.
Source
Subject
*ANTICONVULSANTS
*PARTIAL epilepsy
*DRUG efficacy
*DRUG tolerance
*HYPONATREMIA
*THERAPEUTICS
*DISEASE risk factors
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Language
ISSN
0001-6314
Abstract
Purpose Evaluate real-life experience with eslicarbazepine acetate ( ESL) after first monotherapy failure in a large series of patients with focal epilepsy. Method Multicentre, retrospective, 1-year, observational study in patients older than 18 years, with focal epilepsy, who had failed first antiepileptic drug monotherapy and who received ESL. Data from clinical records were analysed at baseline, 3, 6 and 12 months to assess effectiveness and tolerability. Results Eslicarbazepine acetate was initiated in 253 patients. The 1-year retention rate was 92.9%, and the final median dose of ESL was 800 mg. At 12 months, 62.3% of patients had been seizure free for 6 months; 37.3% had been seizure free for 1 year. During follow-up, 31.6% of the patients reported ESL-related adverse events ( AEs), most commonly somnolence (8.7%) and dizziness (5.1%), and 3.6% discontinued due to AEs. Hyponatraemia was observed in seven patients (2.8%). After starting ESL, 137 patients (54.2%) withdrew the prior monotherapy and converted to ESL monotherapy; 75.9% were seizure free, 87.6% were responders, 4.4% worsened, and 23.4% reported ESL-related AEs. Conclusion Use of ESL after first monotherapy failure was associated with an optimal seizure control and tolerability profile. Over half of patients were converted to ESL monotherapy during follow-up. [ABSTRACT FROM AUTHOR]