부산대학교 도서관

Background: In patients with critical illness, damage to the body's natural flora and the overgrowth of pathogenic bacteria are common. Probiotics can act as protectors of the intestinal barrier and reduce the overgrowth of pathogens. The purpose of this systematic review is the overall assessment of the effectiveness of probiotics and synbiotic mixtures to reduce the transmission and prevention of nosocomial infections. Methods: Date bases of Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library) PubMed/MEDLINE, EMBASE, CINAHL, Google Scholar, Scopus, Web of Science, and ISI were used. All Randomized and Controlled Trials (RCT) related to clinical outcomes Probiotic therapy as a single strategy or in combination with prebiotic fiber (Synbiotics) were selected. Results: A total of 79 related studies were identified from different databases 49 of them were removed. Finally, 30 RCTs met our inclusion criteria and a total of 2972 patients were studied. According to studies, there was a significant reduction in infections with a significant reduction in the incidence of ventilator-associated pneumonia (VAP) with probiotic therapy. No effect on mortality or diarrhea was observed in these studies. Conclusions: The use of probiotics in reducing infections, including VAP, in patients with critical illnesses is promising. However, due to the heterogeneity of the results of clinical and hospital studies, more studies are needed to definitively express this effect. [ABSTRACT FROM AUTHOR]