부산대학교 도서관

The first two methods are associated with an increase in the average refractive index of tissue by replacing tissue water with a fluid with a higher refractive index. The term "tissue optical clearing" (TOC) came into use at the end of the 20th century and is associated with the development of methods for controlling tissue scattering properties using the refractive index matching effect. In these cases, TOC protocols should also provide for increasing the permeability of tissues and ensuring the safety and reversibility of the procedure. The rapid evolution of optical diagnostic and research methods induced comprehensive study of the mechanisms of TOC, a search for new approaches and optical clearing agents (OCAs). [Extracted from the article]