학술논문

Extracellular nicotinamide phosphoribosyltransferase, a new cancer metabokine.
Document Type
Journal Article
Source
British Journal of Pharmacology. Jul2016, Vol. 173 Issue 14, p2182-2194. 13p.
Subject
*Nicotinamide
*Phosphoribosyltransferases
*Metabolism
*B cells
*Cancer immunotherapy
*Cytokines
*Cell metabolism
*Animals
*Cell physiology
*Transferases
*Tumors
Language
ISSN
0007-1188
Abstract
In this review, we focus on the secreted form of nicotinamide phosphoribosyltransferase (NAMPT); extracellular NAMPT (eNAMPT), also known as pre-B cell colony-enhancing factor or visfatin. Although intracellular NAMPT is a key enzyme in controlling NAD metabolism, eNAMPT has been reported to function as a cytokine, with many roles in physiology and pathology. Circulating eNAMPT has been associated with several metabolic and inflammatory disorders, including cancer. Because cytokines produced in the tumour micro-environment play an important role in cancer pathogenesis, in part by reprogramming cellular metabolism, future improvements in cancer immunotherapy will require a better understanding of the crosstalk between cytokine action and tumour biology. In this review, the knowledge of eNAMPT in cancer will be discussed, focusing on its immunometabolic function as a metabokine, its secretion, its mechanism of action and possible roles in the cancer micro-environment. [ABSTRACT FROM AUTHOR]