학술논문
Rapid Nanopore Whole-Genome Sequencing for Anthrax Emergency Preparedness.
Document Type
Journal Article
Author
McLaughlin, Heather P.; Bugrysheva, Julia V.; Conley, Andrew B.; Gulvik, Christopher A.; Cherney, Blake; Kolton, Cari B.; Marston, Chung K.; Saile, Elke; Swaney, Erin; Lonsway, David; Gargis, Amy S.; Kongphet-Tran, Thiphasone; Lascols, Christine; Michel, Pierre; Villanueva, Julie; Hoffmaster, Alex R.; Gee, Jay E.; Sue, David
Source
Subject
*CIVIL defense
*ANTHRAX
*DRUG resistance in microorganisms
*BACILLUS anthracis
*PUBLIC health
*DISASTERS
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Language
ISSN
1080-6040
Abstract
Human anthrax cases necessitate rapid response. We completed Bacillus anthracis nanopore whole-genome sequencing in our high-containment laboratory from a human anthrax isolate hours after receipt. The de novo assembled genome showed no evidence of known antimicrobial resistance genes or introduced plasmid(s). Same-day genomic characterization enhances public health emergency response. [ABSTRACT FROM AUTHOR]