학술논문
Creation of a pandemic memory by tracing COVID-19 infections and immunity in Luxembourg (CON-VINCE).
Document Type
Article
Author
Tsurkalenko, Olena; Bulaev, Dmitry; O'Sullivan, Marc Paul; Snoeck, Chantal; Ghosh, Soumyabrata; Kolodkin, Alexey; Rommes, Basile; Gawron, Piotr; Moreno, Carlos Vega; Gomes, Clarissa P. C.; Kaysen, Anne; Ohnmacht, Jochen; Schröder, Valerie E.; Pavelka, Lukas; Meyers, Guilherme Ramos; Pauly, Laure; Pauly, Claire; Hanff, Anne-Marie; Meyrath, Max; Leist, Anja
Source
Subject
*COVID-19
*COVID-19 pandemic
*LONELINESS
*SARS-CoV-2
*IMMUNITY
*PSYCHOLOGICAL factors
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Language
ISSN
1471-2334
Abstract
Background: During the COVID-19 pandemic swift implementation of research cohorts was key. While many studies focused exclusively on infected individuals, population based cohorts are essential for the follow-up of SARS-CoV-2 impact on public health. Here we present the CON-VINCE cohort, estimate the point and period prevalence of the SARS-CoV-2 infection, reflect on the spread within the Luxembourgish population, examine immune responses to SARS-CoV-2 infection and vaccination, and ascertain the impact of the pandemic on population psychological wellbeing at a nationwide level. Methods: A representative sample of the adult Luxembourgish population was enrolled. The cohort was followed-up for twelve months. SARS-CoV-2 RT-qPCR and serology were conducted at each sampling visit. The surveys included detailed epidemiological, clinical, socio-economic, and psychological data. Results: One thousand eight hundred sixty-five individuals were followed over seven visits (April 2020—June 2021) with the final weighted period prevalence of SARS-CoV-2 infection of 15%. The participants had similar risks of being infected regardless of their gender, age, employment status and education level. Vaccination increased the chances of IgG-S positivity in infected individuals. Depression, anxiety, loneliness and stress levels increased at a point of study when there were strict containment measures, returning to baseline afterwards. Conclusion: The data collected in CON-VINCE study allowed obtaining insights into the infection spread in Luxembourg, immunity build-up and the impact of the pandemic on psychological wellbeing of the population. Moreover, the study holds great translational potential, as samples stored at the biobank, together with self-reported questionnaire information, can be exploited in further research. Trial registration: Trial registration number: NCT04379297, 10 April 2020. [ABSTRACT FROM AUTHOR]