학술논문
KAEA (SUDPRO), a member of the ubiquitous KEOPS/EKC protein complex, regulates the arginine catabolic pathway and the expression of several other genes in Aspergillus nidulans.
Document Type
Article
Author
Source
Subject
*ASPERGILLUS nidulans
*SACCHAROMYCES cerevisiae
*ENDOPEPTIDASES
*TRANSFER RNA
*GENETIC mutation
*ARGININE
*KINASES
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Language
ISSN
0378-1119
Abstract
The kaeA KAE1 ( suDpro ) gene, which was identified in Aspergillus nidulans as a suppressor of proline auxotrophic mutations, encodes the orthologue of Saccharomyces cerevisiae Kae1p, a member of the evolutionarily conserved KEOPS/EKC (Kinase, Endopeptidase and Other Proteins of Small size/Endopeptidase-like and Kinase associated to transcribed Chromatin) complex. In yeast, this complex has been shown to be involved in tRNA modification, transcription, and genome maintenance. In A. nidulans , mutations in kaeA result in several phenotypic effects, the derepression of arginine catabolism genes, and changes in the expression levels of several others, including genes involved in amino acid and siderophore metabolism, sulfate transport, carbon/energy metabolism, translation, and transcription regulation, such as rcoA TUP1 , which encodes the global transcriptional corepressor. [ABSTRACT FROM AUTHOR]