학술논문
Age- and airway disease related gene expression patterns of key SARS-CoV-2 entry factors in human nasal epithelia.
Document Type
Article
Source
Subject
*NASAL mucosa
*SARS-CoV-2
*COVID-19 pandemic
*GENE expression
*ANGIOTENSIN converting enzyme
*COVID-19
*AIRWAY (Anatomy)
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Language
ISSN
0042-6822
Abstract
The global COVID-19 pandemic caused by SARS-CoV-2 predominantly affects the elderly. Differential expression of SARS-CoV-2 entry genes may underlie the variable susceptibility in different patient groups. Here, we examined the gene expression of key SARS-CoV-2 entry factors in mucosal biopsies to delineate the roles of age and existing chronic airway disease. A significant inverse correlation between ACE2 and age and a downregulation of NRP1 in patients with airway disease were noted. These results indicate that the interplay between various factors may influence susceptibility and the disease course. • COVID-19 mostly affects the elderly. • ACE2 expression is age related; children have the highest ACE2 levels. • Lower ACE2 skews cell toward the inflammatory. • Chronic airway disease affects NRP1 levels. [ABSTRACT FROM AUTHOR]