학술논문
Understanding the Mechanism of Action of the Novel SSAO Substrate (C7 NH10 )6 (V10 O28 )·2H2 O, a Prodrug of Peroxovanadate Insulin Mimetics.
Document Type
Article
Author
Source
Subject
*MONOAMINE oxidase
*PRODRUGS
*DIABETES
*AMINE oxidase
*HYPOGLYCEMIC agents
*MEDICAL research
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Language
ISSN
1747-0277
Abstract
A new vanadium salt, hexakis(benzylammonium) decavanadate (V) dihydrate (C7NH10)6(V10O28)·2H2O ( 1 ), has been synthesized as well as characterized chemically and biologically. An in vitro enzyme assay revealed that compound 1 is oxidized to the same extent as a combination of benzylamine and vanadate by the enzyme semicarbazide-sensitive amine oxidase (SSAO), and therefore can be considered an SSAO substrate. It also stimulates glucose uptake in isolated rat adipocytes in a dose-dependent manner. We describe here the results of 51V-NMR experiments that, combined with the in vitro results, corroborate that compound 1 could act as a prodrug of di-peroxovanadate ([V(OH)2(OO)2(OH)2]2−) insulin mimetics. [ABSTRACT FROM AUTHOR]