부산대학교 도서관

The aim of the present study is to analyze the effects of liver cirrhosis and protein undernutrition on bone Cd, Pb, Zn, Cu, Mn, and Fe, and the relationships between bone content of these elements and histomorphometrically assessed bone changes (trabecular bone mass (TBM) and osteoid), serum levels of hormones involved in bone homeostasis (PTH, IGF-1), osteocalcin and hydroxyproline excretion. Four groups of 10 Sprague-Dawley adult rats were fed an 18% protein-containing diet (Group 1), a 2% protein-containing diet (Group 2); Carbon tetrachloride (CCl4) liver cirrhosis was induced in Group 3 (fed a 18% protein-containing diet), and Group 4 (fed a 2% protein-containing diet). Cirrhotic rats, especially those of Group 4, showed significantly decreased TBM (F = 3.89, p = 0.019). Although bone trace elements were not significantly different among the 4 experimental groups, bone Cd showed an inverse relationship with osteoid (rho = -0.45, p = 0.007) and IGF-I (rho = -0.41, p = 0.015), and bone zinc a direct one (rho = 0.36, p = 0.041). We conclude that CCl4-induced liver cirrhosis does not lead to significant changes in bone content of Cd, Pb,Mn, Cu, Zn and Fe, but to a decreased trabecular bone mass. However, bone zinc seems to exert a protective effect on bone changes, showing a direct relationship with osteoid, in contrast with bone cadmium, which keeps an inverse correlation with osteoid area. [ABSTRACT FROM AUTHOR]