학술논문
Ten simple rules for conducting a mendelian randomization study.
Document Type
Editorial
Source
Subject
*INSTRUMENTAL variables (Statistics)
*MENDEL'S law
*GENETIC variation
*GENOME-wide association studies
*GENETIC epidemiology
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Language
ISSN
1553-734X
Abstract
Non-linear MR (Testing for non-linear causal effects using a binary genotype in a Mendelian randomization study: application to alcohol and cardiovascular traits. These different methods include, but are not limited to, random effects MR, the MR modal-based estimator [[23]], weighted median MR [[24]], MR-Egger regression [[25]], MR-robust adjusted profile score (RAPS) [[26]], and simulation-based heterogeneity and outlier tests (e.g., MR-pleiotropy residual sum and outlier (PRESSO)) [[27]]. Mendelian randomization (MR) is an epidemiological technique for estimating causal relationships using observational data, which has become very popular in recent years following publication of a seminal article by Smith and Ebrahim in 2003 [[1]]. [Extracted from the article]