학술논문
Noninvasive minimal residual disease assessment in relapsed/refractory large B‐cell lymphoma using digital droplet PCR.
Document Type
Article
Author
Heger, Jan‐Michel; d'Hargues, Yannick; Kleinert, Fanni; Mattlener, Julia; Weiss, Jonathan; Franzen, Fabian; Becker, Christian; Becker, Kerstin; Gödel, Philipp; Schmiel, Marcel; Meinel, Jörn; Flümann, Ruth; Simon, Florian; Reinhardt, H. Christian; Borchmann, Peter; Borchmann, Sven; Balke‐Want, Hyatt; Knittel, Gero; von Tresckow, Bastian
Source
Subject
*DIFFUSE large B-cell lymphomas
*LYMPHOMAS
*DNA sequencing
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Language
ISSN
0902-4441
Abstract
Although several promising approaches for the treatment of relapsed/refractory diffuse large B‐cell lymphoma (rrDLBCL) have been approved recently, it remains unclear which patients will ultimately achieve long‐term responses. Circulating tumor (ct)DNA sequencing has emerged as a valuable tool to assess minimal residual disease (MRD). Correlations between MRD and outcomes have been shown in previously untreated DLBCL, but data on the repeated assessment of MRD in the dynamic course of rrDLBCL is limited. Here, we present an approach leveraging cost‐ and time‐sensitivity of digital droplet (dd)PCR to repeatedly assess MRD in rrDLBCL and present proof‐of‐principle for its ability to predict outcomes. [ABSTRACT FROM AUTHOR]