학술논문
Analysis of fatality impact and seroprevalence surveys in a community sustaining a SARS-CoV-2 superspreading event.
Document Type
Article
Author
Source
Subject
*SUPERSPREADING events
*SEROPREVALENCE
*SARS-CoV-2
*DEATH certificates
*COVID-19
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*
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Language
ISSN
2045-2322
Abstract
There is an ongoing debate on the COVID-19 infection fatality rate (IFR) and the impact of COVID-19 on overall population mortality. Here, we addressed these issues in a community in Germany with a major superspreader event analyzing deaths over time and auditing death certificates in the community.18 deaths that occurred within the first six months of the pandemic had a positive test for SARS-CoV-2. Six out of 18 deaths had non-COVID-19 related causes of death (COD). Individuals with COVID-19 COD typically died of respiratory failure (75%) and tended to have fewer reported comorbidities (p = 0.029). Duration between first confirmed infection and death was negatively associated with COVID-19 being COD (p = 0.04). Repeated seroprevalence essays in a cross-sectional epidemiological study showed modest increases in seroprevalence over time, and substantial seroreversion (30%). IFR estimates accordingly varied depending on COVID-19 death attribution. Careful ascertainment of COVID-19 deaths is important in understanding the impact of the pandemic. [ABSTRACT FROM AUTHOR]