학술논문
Grape-Seed Polyphenolic Extract Improves the Eye Phenotype in a Drosophila Model of Tauopathy.
Document Type
Article
Author
Source
Subject
*MEDICAL research
*PATIENTS
*NEURODEGENERATION
*CARE of Alzheimer's patients
*BIOMARKERS
*DIFFERENTIAL diagnosis
*PHENOTYPES
*DROSOPHILA genetics
*MICROBIAL aggregation
*DISEASES
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Language
ISSN
2090-0252
Abstract
Drosophila models of tauopathies have been developed by transgenically overexpressing the disease-associated forms of tau. In this paper we report for the first time that a recently developed Grape-Seed Polyphenolic Extract (GSPE) improves the eye phenotype of a Drosophila eye model of R406W tau. GSPE-mediated improvements in this distinct in vivo neurodegeneration model for protein misfolding/aggregation suggest that GSPE may have therapeutic value in disorders involving aberrant protein aggregation. [ABSTRACT FROM AUTHOR]