학술논문
Diverse Phenotypes and Specific Transcription Patterns in Twenty Mouse Lines with Ablated LincRNAs.
Document Type
Article
Author
Lai, Ka-Man Venus; Gong, Guochun; Atanasio, Amanda; Rojas, José; Quispe, Joseph; Posca, Julita; White, Derek; Huang, Mei; Fedorova, Daria; Grant, Craig; Miloscio, Lawrence; Droguett, Gustavo; Poueymirou, William T.; Auerbach, Wojtek; Yancopoulos, George D.; Frendewey, David; Rinn, John; Valenzuela, David M.
Source
Subject
*PHENOTYPES
*GENETIC transcription
*LINCRNA
*ANIMAL morphology
*MICE physiology
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Language
ISSN
1932-6203
Abstract
In a survey of 20 knockout mouse lines designed to examine the biological functions of large intergenic non-coding RNAs (lincRNAs), we have found a variety of phenotypes, ranging from perinatal lethality to defects associated with premature aging and morphological and functional abnormalities in the lungs, skeleton, and muscle. Each mutant allele carried a lacZ reporter whose expression profile highlighted a wide spectrum of spatiotemporal and tissue-specific transcription patterns in embryos and adults that informed our phenotypic analyses and will serve as a guide for future investigations of these genes. Our study shows that lincRNAs are a new class of encoded molecules that, like proteins, serve essential and important functional roles in embryonic development, physiology, and homeostasis of a broad array of tissues and organs in mammals. [ABSTRACT FROM AUTHOR]