부산대학교 도서관

Background: SRBDs have been shown to increase the risk of cardiovascular disease, which is a significant cause of mortality in kidney transplant recipients. Few studies have investigated the association between SRBDs and cardiometabolic risk factors in pediatric kidney transplant recipients. Methods: This was a cross‐sectional study of pediatric kidney transplant recipients using baseline cardiometabolic data from a previous clinical trial (NCT01007994). Parents/guardians of pediatric kidney transplant recipients filled out 22‐item PSQ. A score greater than 33% was defined as a diagnosis of a SRBD. Fisher's exact test, Mann–Whitney U test, and regressions were used to determine associations. Results: Among the 58 transplant recipients enrolled, 14.80% (n = 8) of participants identified as Black and 40.7% (n = 22) were male. The median age was 13 (IQR 8.25, 17) years and median number of years post‐transplant for participants was 2 (IQR 1, 4). The prevalence of SRBDs was 26% (n = 14). The presence of a SRBD was associated with abnormalities in multiple cardiometabolic risk factors including total cholesterol level (β = 23.63; 95% CI 3.58–43.67), LDL level (β = 24.94; 95% CI 6.37–43.50), triglyceride level (β = 54.62; 95% CI 8.74–100.50), and LVH (OR = 5.12; 95% CI 1.12–23.45) when adjusted for age, sex, and race. Conclusions: Similar to associations reported in the general pediatric and general CKD populations, SRBD is associated with increased cardiometabolic risk in pediatric kidney transplant recipients. [ABSTRACT FROM AUTHOR]