학술논문
No evidence for viral sequences in five lepidic adenocarcinomas (former "BAC") by a high-throughput sequencing approach.
Document Type
Article
Author
Source
Subject
*ADENOCARCINOMA
*BRONCHOALVEOLAR lung cancer
*JAAGSIEKTE sheep retrovirus
*NON-small-cell lung carcinoma
*HISTOLOGY
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Language
ISSN
1756-0500
Abstract
Background: The hypothesis of an infectious etiology of the formerly named bronchiolo-alveolar carcinoma (BAC) has raised controversy. We investigated tumor lung tissues from five patients with former BAC histology using high-throughput sequencing technologies to discover potential viruses present in this type of lung cancer. Around 180 million single reads of 100 bases were generated for each BAC sample. Results: None of the reads showed a significant similarity for Jaagsiekte sheep retrovirus (JSRV) and no other viruses were found except for endogenous retroviruses. Conclusions: In conclusion, we have demonstrated the absence of JSRV and other known human viruses in five samples of well-characterized lepidic adenocarcinoma. [ABSTRACT FROM AUTHOR]