학술논문

Inhaled Beclomethasone Dipropionate Acutely Stimulates Dose-Dependent Growth Hormone Secretion in Healthy Subjects.
Document Type
Article
Source
CHEST. Aug2005, Vol. 128 Issue 2, p902-905. 4p.
Subject
*ADRENOCORTICAL hormones
*SOMATOTROPIN
*ANTI-inflammatory agents
*ASTHMA
*OBSTRUCTIVE lung diseases
*DRUGS
Language
ISSN
0012-3692
Abstract
The article evaluates whether administration of inhaled corticosteroids could acutely stimulate growth hormone (GH) secretion, and whether this effect could be dose related. Inhaled corticosteroids are the most effective and widely used anti-inflammatory drugs for the treatment of bronchial asthma, and to such an extent they have been incorporated into national as well as international guidelines. Systemic administration of corticosteroids has a dual effect on GH secretion in man--long-term administration consistently blocks GH release, leading to a possible growth delay in childhood, whereas acute systemic administration stimulates GH release.