학술논문

Representing virus-host interactions and other multi-organism processes in the Gene Ontology.
Document Type
Article
Source
BMC Microbiology. Jul2015, Vol. 15 Issue 1, p1-12. 12p.
Subject
*GENE ontology
*HOST-virus relationships
*PROKARYOTES
*BIOINFORMATICS
*VIRAL genomes
*PATHOGENIC viruses
*RNA viruses
Language
ISSN
1471-2180
Abstract
Background: The Gene Ontology project is a collaborative effort to provide descriptions of gene products in a consistent and computable language, and in a species-independent manner. The Gene Ontology is designed to be applicable to all organisms but up to now has been largely under-utilized for prokaryotes and viruses, in part because of a lack of appropriate ontology terms. Background: The Gene Ontology project is a collaborative effort to provide descriptions of gene products in a consistent and computable language, and in a species-independent manner. The Gene Ontology is designed to be applicable to all organisms but up to now has been largely under-utilized for prokaryotes and viruses, in part because of a lack of appropriate ontology terms. Conclusions: Building on the microbial resources already in existence such as ViralZone, UniProtKB keywords and MeGO, this project provides an integrated ontology to describe interactions between microbial species and their hosts, with mappings to the external resources above. Housing this information within the freely-accessible Gene Ontology project allows the classes and annotation structure to be utilized by a large community of biologists and users. [ABSTRACT FROM AUTHOR]